The Deadly Wound is crisis that happens to the one world government during the tribulation that would potentially bring the whole system crashing down. However, before the government descends into chaos, antichrist will appear and heal this deadly head wound and restore the authority and power of the one world political system (Rev 13:1-3) and transform it into a one world religious system with himself as its leader (Rev 13:4-18).
This wound occurs in one of the political heads of the system, which represents one of seven world nations roughly outlined by the continents, and it threatens the authority of this government which has been established under satan’s power and influence (Rev 13:3-4). At the end of the first half of the tribulation, the enforced world peace will be threatened when war breaks out in the Middle Eastern Head and it will culminate with the city of Jerusalem being surrounded by armies (Luke 21:20-21), at which point satan will enter in and wipe out the armies that come against it (Rev 13:3). These armies will be comprised of forces of other Middle Eastern nations, and fortified by Russian forces (Eze 38 in a physical sense), while supporting the nation of Israel, at least in spirit, will be the Christian nations of the world, the US with a coalition of European nations, most likely also including Canada and Australia as well. Russia will have betrayed these nations of the coalition in backing these middle eastern nation because traditionally Russia is a Christian nation (Dan 7:5).
The one world political system is the creation of satan (Rev 13:4), and it is absolutely essential for his plan for world tyranny, when he comes in as antichrist, so when this Deadly Wound occurs, he knows he must come in to fix it because he is very familiar with the scripture that says every kingdom divided against itself shall be brought to a desolation (Matt 12:25-26, Mark 3:23-26, Luke 11:17-20). This kingdom of his must be stable and solid to remain functional, but true peace cannot be enforced because tensions and hatreds will fester behind the scenes, and when those tensions get too high, they will boil over into a war that is the deadly wound. There cannot be true peace or love without Jesus Christ (Isa 57:20-21), and this government will certainly not have Him as their standard, and this is why it is ultimately destined to fail. There will be no world peace until Jesus returns and the flesh is done away with (Isa 59:1-10, Jer 6:10-15, 8:8-11, 12:10-13, Eze 13:9-16).
The world will believe that Jerusalem will be on the verge of destruction and so they will mistakenly identify this event as the Battle of Armageddon (Eze 38 in a spiritual sense, Rev 16:12-16), and so when satan comes in to heal this deadly wound by stopping the hostilities in a grand entrance (Eze 39 in a physical sense, Rev 16:17-21, 18-19), they will believe he is Jesus Christ, or their respective messiah, coming to bring true world peace. They will worship satan, the antichrist (Rev 13:11-14), and will want to truly establish this world peace because they think that he is the Savior of the world (2Thess 2:3-12), and they will feel peace and love in their hearts because of his deception. The people of the world will believe that there can no longer be any more war once this second beast comes to de facto power (1Thess 5:3), but it won’t be until the true Christ returns, months later, that the world will finally see true peace because our one and only Savior will have finally come to earth to establish His Millennium Kingdom (Eze 39-48, Zech 14, Rev 20).
For more information, check out this article: The Deadly Wound